Steps the Doctor May Take
To see if Exelon Patch is right for your loved one, the health care professional will start him or her on the initial daily dose of 4.6 mg/24 hours. It is designed to determine how well your loved one is tolerating the medication.
After 4 weeks, if your loved one is tolerating the medication, he or she could move up to the effective dose of 9.5 mg/24 hours if instructed by the health care professional. For special populations (patients under 50 kg [110 lb] and patients with mild to moderate hepatic impairment), the health care professional will consider using Exelon Patch 4.6 mg/24 hours as the initial and maintenance dose.
When greater benefit is needed while on the 9.5 mg/24 hours patch and if still well tolerated for 4 weeks, your loved one's health care professional may prescribe the maximum effective dose of 13.3 mg/24 hours.
The Story Behind Our Maximum Effective Dose
Exelon Patch is the first skin patch proven effective across all stages of Alzheimerís disease—mild, moderate, and severe.
The 13.3 mg/24 hours Exelon Patch is our maximum effective dose. In appropriate patients, this dose can be part of a treatment plan if additional benefit is needed for your loved one after the appropriate titration doses and periods. Overall frequency of side effects is similar across all doses of Exelon Patch, but specific side effects were generally higher in the 13.3 mg/24 hours Exelon Patch.
In a 48-week clinical trial, the 13.3 mg/24 hours patch was compared to the 9.5 mg/24 hours patch. For mild to moderate patients treated with the 9.5 mg/24 hours patch who were still declining, the 13.3 mg/24 hours patch helped with overall function (doing daily tasks). Overall frequency of side effects is similar across all doses of Exelon Patch, but specific side effects were generally higher in the 13.3 mg/24 hours patch vs the 9.5 mg/24 hours patch.
One of the measures used in the trial to assess overall function was the Instrumental Activities of Daily Living (ADCS-IADL).
Instrumental Activities of Daily Living (IADLs)
IADLs are signs of independence. IADL stands for Instrumental Activities of Daily Living. Those are things like making a meal. Conversing. Or traveling outside the home. IADLs are used to gauge a patient's independence. And they are things that you, as a caregiver, should be watching closely. The longer your loved one can maintain their independence, the better. But if your loved one's ability to do these things has changed, it may be a sign of worsening memory problems. And may point to the need for the 13.3 mg/24 hours patch. Here are the things you should be looking for:
EXELON PATCH improves overall function and cognition.
In a study of patients with severe Alzheimer's symptoms, those treated with the 13.3 mg/24 hours patch had significant improvement in cognition and improvement in daily activities, such as socializing, housekeeping, and making decisions vs patients treated with the 4.6 mg/24 hours patch.